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Regulation of irg expression by interferons: Our data suggest that IRF-1 participates in the transient formation of an induction-specific complex es with the regulatory elements.
Structure of a chromosomal gene for human interferon beta. A nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus. Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. A rapid and sensitive assay system for bacterial gpt activity in transfected mammalian cells.
Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Intracytoplasmic phosphorylation sites of Tac antigen p55 are not essential for the conformation, function, and regulation of the human interleukin 2 receptor.
Reversible silencing of enhancers by sequences derived from the human IFN-alpha promoter.
IRFS4610 MOSFET. Datasheet pdf. Equivalent
High efficiency DNA-mediated transformation of primate cells. In this study, we describe a nuclear factor, termed interferon regulatory factor-1 IRF-1that is involved in the transcription of IFN-beta and possibly other genes. Human embryonic lung cells HEL-R66 are of monkey origin. Heat shock factor is regulated differently in yeast and HeLa cells. The 5′-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription.
Abstract Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene. Controlled transcription of a human alpha-interferon gene introduced into mouse L cells.
Biochemistry of interferons and their actions. Support Center 46100 Center. Open in a separate window.
Short and long range activation by the SV40 enhancer. This article has been cited by other articles in PMC. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.
Author information Copyright and License information Disclaimer. Images in this article Image on p. IRF-1 may also be involved in silencing the function of the SV40 enhancer juxtaposed to the regulatory elements in uninduced cells.
IRF International Rectifier Corp.
Associated Data Supplementary Materials. Affinity purification of sequence-specific DNA binding proteins.
The human beta-interferon gene enhancer is under negative control. Changes of chromatin conformation around mouse interferon-beta gene associated with induction of interferon synthesis.
BK viral enhancer element and a human cellular homolog.
Human beta-interferon gene expression is regulated by an inducible enhancer element. Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. Interaction of positive and negative regulatory proteins in the galactose regulon of yeast.