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CORONCINA E NOVENA ALLA DIVINA MISERICORDIA PDF

Coroncina e novena alla divina misericordia by M. Faustina Kowalska, , available at Book Depository with free delivery worldwide. This site uses proprietary and third party cookies to offer a better user experience. By continuing to browse the site, you are agreeing to our use of cookies. Composition: Divine Mercy chaplet 50% and a folding ”Worship of the Divine Mercy” 50%. Contraindications: None. Therapeutic indications: against spiritual.

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Coroncina e novena alla divina misericordia : M. Faustina Kowalska :

Dacci oggi il nostro pane quotidiano, e rimetti a noi i nostri debiti, come noi li rimettiamo ai nostri debitori, e non ci indurre in tentazione ma liberaci dal male. Santa Maria, Madre di Dio, prega per noi peccatori, adesso e nell’ora della nostra morte. Gloria al Padre e al Figlio e allo Spirito Santo.

Ala era nel principio e ora e sempre, nei secoli dei secoli. Ti supplichiamo per l’amore che Nkvena unisce al Padre ed allo Spirito Santo.

Essi Mi hanno dato la forza di superare l’amara Passione. La fonte dell’amore di Dio, Alberga nei cuori limpidi, Purificati nel mare della Misericordia, Luminosi come le stelle, chiari come l’aurora. Queste anime Mi hanno confortato lungo la strada del Calvario, sono state una goccia di conforto in un mare di amarezza.

Te ne supplichiamo per l’ineffabile amore, di ccoroncina il Tuo Cuore arde per il Padre Celeste. A tutti rivolgi sguardi di compassione, E attiri tutti al Tuo amore. Anche a loro ho pensato nella Mia amara Passione e il loro futuro zelo ha consolato il Mio Cuore.

Immergili nel mare della Mia Misericordia. Attirale alla luce del Vangelo. Eterno Padre, guarda con gli occhi della Misericodia Misericordia alle anime degli eretici e degli scismatici, che hanno dissipato i Tuoi beni ed hanno abusato delle Tue grazie, perdurando ostinatamente nei loro errori. Fa’ che anche essi lodino la Tua grande Misericordia per i secoli dei secoli.

Esse Mi hanno sostenuto nell’amaro travaglio dell’agonia. Li ho visti come gli angeli della terra che avrebbero vigilato presso i Miei altari. Su di loro riverso le Mie grazie a pieni torrenti.

Queste anime attirano l’ammirazione di tutto il paradiso e formano lo speciale compiacimento del Padre Celeste; sono un mazzo di fiori davanti al trono di Dio, del cui profumo si delizia Dio stesso.

Esse sono un riflesso vivente del Mio Cuore pietoso.

Coroncina e novena alla divina misericordia

I torrenti del Mio Sangue attenuino la loro arsura. Prendi dal tesoro della Mia Chiesa tutte le indulgenze ed offrile per loro Oh, se conoscessi i loro tormenti, offriresti continuamente per loro l’elemosina dello spirito e pagheresti i debiti che essi hanno nei confronti della mia giustizia!

Dall’arsura tremenda del fuoco del purgatorio, S’innalza un lamento alla Tua Misericordia, E ricevono conforto, sollievo e refrigerio Nel torrente formato dal Sangue e dall’Acqua. Sono state loro la causa per cui ho detto: Per loro, ricorrere alla Mia Misericordia costituisce l’ultima tavola di salvezza.

Coroncina e Novena alla Divina Misericordia – Jesus I trust in you Italy – Apostles of Divine Mercy

Possano riscaldarsi nel Tuo puro amore queste anime di ghiaccio, che assomigliano a cadaveri e suscitano in te tanta ripugnanza. Padre della Misericordia, Ti supplico per l’amarezza della Cooncina del Tuo Figlio e per la Sua agonia di tre ore sulla croce, permetti che anche loro lodino l’abisso della Tua Misericordia Usiamo la corona del Rosario. Sui grani del Gloria si recita la frase seguente: Sui grani dell’ Ave Maria si recita la frase seguente x Per la sua dolorosa Passione abbi misericordia di noi e del mondo intero.

ERACLITO FRAMMENTI PDF

Eraclito Raccolta dei frammenti e traduzione italiana di Ricardus Walzer [ Ricardus [Richard] Walzer] on *FREE* shipping on qualifying offers . Donor challenge: Your generous donation will be matched 2-to-1 right now. Your $5 becomes $15! Dear Internet Archive Supporter,. I ask only. Eraclito I frammenti e le testimonianza Fondazione Lorenzo Valla (Mondadori).

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Eraclito Frammenti e Testimonianze | Eraclito I frammenti e … | Flickr

Francesco Fronterotta gives us a very good edition of the fragments of Heraclitus, with a thorough individualized commentary on each text, and a new Italian translation. The main body of ftammenti book just a bit shy of four hundred pages consists of the bilingual edition of the scarce fragments Italian and Greekand an extensive commentary on text and translation, systematically oriented to situating Heraclitus in his historical and philosophical context. The volume opens with a long and substantial Introduction comprising five sections: Fragment, testimonium or quotation: The image of Heraclitus.

Fronterotta deals competently with the necessary generalities and insightfully discusses some of the main themes and problems posed by the texts themselves, as well as several perspectives in the philosophical tradition, ancient and modern.

Besides the introduction, preliminaries include a note on the text, where the editorial method is briefly presented and justified, assuming as basic the editions of Diels-Kranz and Marcovich tables of concordance are provided in the appendix, together with a list of sourcesand a thematically organized bibliography not exhaustive, but paying special attention to works from to As a rule, the commentary does an excellent job at presenting the context of each fragment, without neglecting frammento and even minute textual matters.

It is certainly well written and for committed readers its contents are clear enough and relatively easy to follow through labyrinths of words rich in textual and philosophical problems.

Fronterotta translates this beginning thus: Section 2 closes with a concentration on the theme of becoming and flux, including an insightful treatment of the river fragment B The solar fragments are also included, as well as three fragments from Hippolytus, regarding frammemti Fronterotta concludes with a judicious dismissal of eschatological readings. Section 4 offers a systematization of epistemological ideas, which take off from the eraclit of the epistemic nature and value of the senses.

The grouping ends with texts dealing with ignorance as the defining mark of human perspective in sharp contrast to divine knowledge of the totally unified oppositions, the hidden true nature of things.

Eraclito; testimonianze e frammenti

Section 5 deals with the nature and the functions of the soul, which is viewed within a physical framework. B and B on the wet soul of the drunkard, and its opposite, the dry, wise and luminous soul are etaclito as providing a physiological instantiation of cosmic patterns.

Other relevant fragments B20, B48, B27, and B63 are refreshingly read as a critical revision of human eschatological expectations.

Section 6, the longest, presents fragments dealing with ethics, politics and religion, in a broad sense. The positive ethical paradigm is, frakmenti principle, open to all and grounded in self-knowledge.

This paradigm should be followed also by the many, whose morality is frontally frammfnti and depicted sarcastically as animal behavior. A handful of fragments that frammfnti religious practices and beliefs give a sketch of these as notoriously irrational, while B52, B and B18, the texts selected for the conclusion, are interpreted as a final exhortation to a better kind of life.

The book is exceptionally well presented, the paperback binding is strong and the volume is comfortable to handle.

Eraclito Frammenti – Ghent University Library

The summary is too brief, lacking the subdivisions that structure the introduction, as well as the series of fragments within each section of the edition itself. I deem this splendid book a valuable tool and an important contribution to Heraclitean scholarship, from which interested readers and specialists will benefit for years to come.

Bryn Mawr Classical Review BUR Classici greci e latini, Read comments on this review or add a comment on the BMCR blog.

EL MILAGRO MAS GRANDE DEL MUNDO OG MANDINO PDF

El Milagro Mas Grande Del Mundo (Spanish Edition) [Og Mandino, Raul Bracho] on *FREE* shipping on qualifying offers. Augustine Mandino. La portada y edición del libro puede cambiar. · La portada del libro puede cambiar. These fees are non-negotiable. This is non-negotiable. | eBay!. El Milagro Mas Grande del Mundo by Og Mandino, , available at Book Depository with free delivery worldwide.

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DECRETO ANTITRAMITES 2011 PDF

de , pueden ser diagnosticadas con los reactivos in vitro Pública, concluyó que el decreto cumple con las normas antitrámites. Decreto Por el cual se reglamenta el artículo 17 de la Ley de y se Informe de Ponencia Para Primer debate al Proyecto de Ley 25 de acuerdo comercial con Venezuela · INVIMA aplica disposiciones antitrámites en . of Decree , also known as the Anti-formalities Decree (Decreto Antitrámites). to the executive by the Congress of the Republic under Law of

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Until recently few jurisdictions have allowed arbitration of family law disputes, considering such arbitration to be contrary to public policy. But policies favouring private ordering, combined with pressures on family courts have encouraged reconsideration of the policy issues.

This is notably true in common law jurisdictions.

Similar developments in civil law jurisdictions are inhibited by the wording of national civil codes. Differences in substantive laws and in legal institutions also contribute to diverse assessments of the utility of arbitration: Where arbitration has been promoted, its scope has been limited to the financial consequences of divorce in some jurisdictions, while in others it extends also to child arrangements. Policy concerns are addressed through the development of enhanced protection for the parties to arbitration as compared to commercial cases, whether through case law or legislation.

Key areas in which this has occurred include: According to Part 3.

Mes: abril 2016

One such form of dispute resolution is arbitration. An Institute of Family Law Arbitration IFLA was established in England in with a view to promoting arbitration of family law disputes and providing a framework within which such arbitration could take place under the Arbitration Act England and Wales are not alone.

In recent years institutions conducting or regulating family arbitration have also emerged in, inter aliaGermany, Spain, Australia, and Canada. These include speed, flexible scheduling, more informal procedures, the opportunity to select an appropriate expert as arbitrator, and confidentiality. Lower costs are also claimed.

Although the parties have to pay the arbitrator sthere is less wastage of costs on legal representation dcreto repeated — and wasted — court attendance. This article explores ddcreto development of family arbitration in the jurisdictions identified above, with occasional antitramits to developments elsewhere.

In each case the legal framework for such arbitration is provided by a general arbitration statute, essentially designed for commercial disputes, or by family arbitration legislation which constitutes an amendment of the general statute. Antitramittes article does not extend to out of court dispute resolution in the context of personal, religious, or customary laws. The general regulatory framework for arbitration — which although designed for civil and commercial matters has provided the starting point for regulation of family arbitration — is broadly similar throughout the world, thanks in particular to the work of UN Commission on International Trade Law which produced the New York Convention on the Recognition and Enforcement of Arbitral Awards, establishing criteria for the enforcement of both arbitration agreements and awards, 4 and the Model Law, which has been adopted, with various modifications, in well over 60 states.

Countries with a long history of commercial arbitration retain their individual distinctive features, 6 but certain characteristics of arbitration are well established.

Arbitration is founded on agreement. In essence, parties agree that they will take their dispute to a decision maker whom they trust the arbitrator or arbitral tribunaland abide by the decision of that person or tribunal. It is binding on the parties and can be enforced in the same way as a judgment. A core use of arbitration is in situations where technical, commercial, or professional expertise is essential to the fair resolution of the dispute.

The parties can select an arbitrator in whose expert judgment they have full confidence. Such rules may be incorporated in dispute resolution clauses in a main contract, or in submission agreements, 8 but in practice commercial parties frequently incorporate by reference the rules of an arbitral institution so that they can benefit from the accumulated experience of that institution.

The principal objective of such rules is to ensure that an arbitral tribunal can be established, even if the respondent to the arbitration is uncooperative. Once the tribunal is established, it can itself make decisions to facilitate the smooth operation of the procedure. Arbitration statutes thus typically establish the requirements for the validity of an arbitration agreement; the relationship between courts and tribunals, in terms of judicial scrutiny of the jurisdiction of an arbitral tribunal and the scope for judicial assistance; the default rules applicable in relation to the establishment of a tribunal and to a limited extent the conduct of the arbitration ; the criteria for a valid award and grounds and procedures for challenges to an award; matters relating to enforcement; and rules on fees and costs.

A significant feature of arbitration in most jurisdictions is that it is a single instance method of dispute resolution. This is in keeping with its commercial origins: The principal form of challenge to an arbitration award is a review on essentially jurisdictional and procedural grounds, rather than an appeal in relation to the findings of fact or law.

Exceptions to the single instance model exist. Generally, the trend in commercial arbitration is towards a harmonization of domestic and international rules, and towards restricted review of awards.

It is assumed that the parties are of equal bargaining power and their personal autonomy should be respected. Many of the restrictions on arbitration in family cases have arisen out of the control of church and state over marriage and divorce. Case law on arbitration is also dominated by divorce cases. But the modern family takes many forms. The restrictions may well not be considered applicable in cases arising from the dissolution of a civil union, still less are they relevant to the parting of cohabitants.

Nevertheless, other public policy considerations may still discourage arbitration of such disputes, and where children are involved the state retains a strong interest irrespective of the nature of the adult relationships. In some jurisdictions, provisions of the Civil Code have proved an obstacle to family arbitration. In Spain, for example, Article CC provides: He argues that wider scope for arbitration is problematic both on grounds of the limited autonomy granted to spouses by family laws and because of the greater scope for protection of weaker parties offered by the judicial system.

Similarly, the wording of the Code of Civil Procedure has shaped debates in Germany. The relevant provisions were amended in at the time of reforms of the law relating to arbitration.

Currently Article ZPO provides: An arbitration agreement regarding non-pecuniary claims has legal effect insofar as the parties to the dispute are entitled to conclude a settlement regarding the subject matter of the dispute. A common thread in the story of the development or advocacy of arbitration for the resolution of family law disputes is the overburdening or breakdown of the judicial system.

In that sense, there is a state interest in relieving the courts of as much of their family dispute resolution function as is compatible with the requirements of public policy.

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But substantial public policy grounds for retaining jurisdiction remain. As well as upholding well-established principles such as legal certainty and judicial protection of weaker parties, the state has an interest in ensuring that, as far as possible, any financial settlement between the parties does not impose welfare responsibilities on the state Paulsson, It also has an interest in ensuring that arrangements on separation or divorce are adequate to limit damage to individual family members Gilfrich The tension between these interests is illustrated by the following quotation, addressing the situation in the USA: Couples themselves are not the only ones that may experience financial loss; the government and community also incur losses related to marital or relationship dissolution and conflict.

In many jurisdictions, a divorce can only be granted once issues relating to property, maintenance, and child arrangements have also been resolved. If at the same time a court judgment is necessary to dissolve a marriage there is therefore a disincentive to take such issues to arbitration: That being so, it is not surprising that advocacy of arbitration as a method of dispute resolution in family law matters is in fact occurring in parallel with the dejudicialization of divorce in uncontested cases.

This is particularly true for countries in which the authority to grant a divorce is being conferred on notaries: In Ecuador, 22 Peru, 23 and Brazil, 24 for example, notaries can issue a divorce in non-contentious cases where there are no minor or disabled children involved.

The parties have to provide documents proving the existence of the marriage to the notary, and also their agreement on the matters that need to be resolved for the divorce to be granted. The notary will then inform the registry office, to ensure that the change in status is publicly recorded. The 2011 — proved to be an explosive time in this respect.

In Latvia 30 and Romania 31 notaries were given the authority to grant divorces in uncontested cases, even where there are children involved. Notarized divorce was proposed in France in but not pursued. In countries where arbitration of some family disputes is accepted as permissible, patrimonial claims, such as those relating to the liquidation of a matrimonial regime, are the least controversial, being closest to the existing domain of arbitration.

vademecum8 – Pontificia Universidad Javeriana

The position in Spain and Germany, and the influence of the wording of, respectively, the Civil Code and the Code of Civil Procedure has already been noted. Similar wording can be decreeto in codifications in other jurisdictions.

Elsewhere the matter may be regulated by specific legislation on family arbitration. In Australia the Family Law Act was amended in to permit arbitration by the Family Law Actbut it is expressly limited to property, maintenance, and financial matters. English law on the subject is at an early stage of evolution. There is no legislative framework beyond the Decretk Actso the question of arbitrability depends entirely on case law.

Recent case law has revised this stance, however. Courts have favoured giving effect to an agreement that the parties have come to themselves for the resolution of their financial affairs following divorce, in the absence of overriding public policy concerns, or a vitiating factor such as undue pressure or the exploitation of a dominant position to secure an unreasonable advantage. The decision was taken at a very early stage not to include children matters in arbitration at the time of the launch.

This was after consultation with the Ministry of Justice. There was a perception that children law matters involve very different considerations including different personnel who may need to be involved in adjudications. There would be reference to hearing the voice of the child and possibly even representation of the child.

It may yet be appropriate but it was felt that the IFLA Scheme would be better to succeed initially dealing with financial matters where there may initially be greater demand.

In most US states arbitration of disputes relating to division of assets and alimony has been well established for decades, but additionally in some states disputes relating to child support and child arrangements have been found to be arbitrable — whether as a result of case law or legislation.

The situation similarly differs from province to province in Canada Morris, Any full comparison of family law dispute resolution would have to extend into differences in substantive law, which may reduce the incidents of disputes, and into family and religious cultures which may provide a support network for separating couples and ways of dissipating or suppressing conflict.

The focus here is more limited: But they may have other dispute resolution mechanisms that provide advantages claimed for arbitration Section IV. On the other hand, in states which have adopted a more liberal approach to arbitration of family disputes, amendments to legislation or creative court rulings have sought to accommodate the special features of family law Section IV. The position in California may be used as an illustration of the difficulties of appreciating the role of arbitration in the light of diverse institutional arrangements.

California is identified in writings on family arbitration as taking a restrictive approach. In practice this means that although arbitration concerning property division and spousal support is permitted, binding arbitration in relation to child arrangements is not. But mediation in this context can also have some unusual features. Thus in Ventura County, for example, parents who participate in mediation relating to child arrangements are assigned to a Child Custody Recommending Counsellor CCRCwho is typically a specialist in family therapy or social work.

The CCRC can gather information from the parties themselves and from the children. The courts or the parties themselves may also seek specialist assistance in the proceedings making or implementing decisions on child arrangements. The assistance is usually obtained through the court appointment of a custody evaluator 58 or a referee, 59 who — like an arbitrator — may be a non-lawyer with the desired professional expertise.

In family law disputes a suitably qualified referee, usually referred to as a Special Master, may assist in resolving disputes on patrimonial issues such as the division of matrimonial property, or concerning child arrangements.

A general reference under Code of Civil Procedure section shares some of the features of arbitration: Across the country, professionals not just lawyers are assuming the role to acquire quasi-judicial immunity while performing the function of a parenting coordinator or parenting consultant. In addition, private judging plays a significant role in California, in part as a means for wealthy litigants to avoid publicity, and in part because of cutbacks in financial support for the public courts.

Article 6, section 21 of the California Constitution provides: A private judge will sign the same oath of office administered to Superior Court judges.

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Sign In Join Now. Register this Author 57 Publications. Supply-side interventions to improve health: PLoS One 16;13 4: Epub Apr Effect of diabetes duration and glycaemic control on year cause-specific mortality in Mexican adults: Lancet Diabetes Endocrinol Jun 19;6 6: Epub Mar Online continuing medical education as a key link for successful noncommunicable disease self-management: Diabetes Metab Syndr Obes 16; Epub Oct mxnual Hypertension 04 21;69 4: Epub Maanual C Consultores, Mexico City, Mexico.

N Engl J Med 11; Gac Med Mex Mar-Apr; 2: Enablers and inhibitors of the implementation of the Casalud Model, a Mexican innovative healthcare model for non-communicable disease prevention and control.

Health Res Policy Syst Jul 22;14 1: Epub Jul Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies. Epub Mar 2.

Roberto Tapia-Conyer

Perspect Public Health Jul 27; 4: Epub Nov Introducing a dengue vaccine to Mexico: A pilot study of a mobile phone application to improve lifestyle and adherence of patients with kidney disease. J Telemed Telecare Mar 13;21 2: Epub Jan Economic and disease burden of dengue in Mexico.

Improving perinatal care in the rural regions worldwide by tzpia enabled antepartum fetal monitoring: Int J Telemed Appl 26; Approaches to refining estimates of global burden and economics of dengue. An unfolding tragedy of Chagas disease in North America.

Preparing for dengue vaccine introduction: Epub Sep Strengthening vaccination policies in Latin America: Vaccine Aug 25;31 Carlos Slim Health Institute, D.

Gac Med Mex Nov-Dec; 6: Rev Invest Clin Jul-Aug;64 4: Accelerating the development of a therapeutic vaccine for human Chagas disease: Expert Rev Vaccines Sep;11 9: Community participation in the prevention and control of dengue: Salud Publica Mex Nov-Dec;44 6: Arch Med Res Nov 6;40 8: Epub Jan 6. What have we learned from the novel influenza A H1N1 pandemic in for strengthening pandemic salyd preparedness?

Arch Med Res Nov 29;40 8: The growing burden tapka dengue in Latin America.

J Clin Virol Oct;46 Suppl 2: Manuak prevalence of chronic diseases and major disease risk factors at different ages amongmen and women living in Mexico City: Epub Jan 9.

Seroepidemiology of giardiasis in Mexico.

Streptococcus pneumoniae isolates in healthy children attending day-care centers in 12 states in Mexico. Salud Publica Mex Jul-Aug;49 4: Individual risk factors for Plasmodium vivax infection in the residual malaria transmission focus of Oaxaca, Mexico.

Salud Publica Mex May-Jun;49 3: Salud Publica Mex Sep-Oct;48 5: Determinant factors for malaria transmission on the coast of Oaxaca State, the main residual transmission focus in Mexico. Salud Publica Mex Jan-Feb;48 1: Int J Epidemiol Apr 23;35 2: Mexico and the tobacco industry: BMJ Mar; Mexican consolidation of the cardiovascular risk factors.

Arch Cardiol Mex Jan-Mar;75 1: Prevalance of proteinuria in Mexico: Kidney Int Suppl Aug Diabetes and hypertension increases in a society with abdominal obesity: Public Health Nutr Feb;8 1: Measles in Mexico, J Infect Dis May; Suppl 1: The high prevalence of overweight and obesity in Mexican children. Obes Res Feb;12 2: Gac Med Mex Jul-Aug; 4: Salud Publica Mex Sep-Oct;45 5: Molecular characterization of anthrax in positive powders: J Clin Microbiol Oct;41 Salud Publica Mex May-Jun;45 3: Final outcomes from the National Health Survey ].

MANUAL DE SALUD PUBLICA ROBERTO TAPIA CONYER EBOOK

Arch Cardiol Mex Jan-Mar;73 1: Results from a large population-based nationwide survey. Diabetes Care Jul;26 7: Salud Publica Mex ;45 Suppl 1: Anthropometric cutoff points for predicting chronic diseases in the Mexican National Health Survey Obes Res Mar;11 3: Emerg Infect Dis Jan;9 1: Implementation and evaluation of a national external quality control program for cervical cytology in Mexico.

Salud Publica Mex Sep-Oct;44 5: Salud Publica Mex Jan-Feb;44 1: Arch Cardiol Mex Jan-Mar;72 1:

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Learn more about Amazon Prime. Please try your request again later. Are you an author? Help us improve our Author Pages by updating your bibliography and submitting a new or current image and biography. Learn more at Author Central. Es un proyecto que cumple dos objetivos largamente perseguidos: Hasta entonces, me podeis seguir en Facebook y Twitter.

Como el amigo de Aznar, el amigo de Granados, el amigo de Camps… porque quien tiene un amigo de esos, hace un tesoro. Y para alcanzarlo nada mejor que colarse en to.

Mire este mapa de casos que pone lo. Que yo sepa, tienen. Como otros muchos, incluyendo los ministros de Justicia e Interior, del Opus, de donde si no iban a ser. Las vidas ejemplares de Rajoy. Mire, hoy no le digo nada y se lo digo todo. Le dejo con las perlas de Rajoy, alias el Bocachancla y sus alabanzas al buen hacer de los condenados Israel, terrorismo de estado, connivencia internacional. Hace tiempo les dejaba un documental sobre las matanzas en Gaza, Erased: No me llamo nena.

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La portada, para El Jueves, es discreta y hubiera pasado desapercibida, noela la dejan estar. Aunque no deja de decir verdad: Una fuerza crecida en apenas cuatro meses al calor del 15M y el 22M que ha roto todas las previsiones y reventado las encuestas demostrado: De Triana a Carromero: A ver que yo me aclare.

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FARMACOS CARDIOTONICOS PDF

Musculo-esqueléticas). D = Sub-capítulo respectivo (Fármacos com Acção na Placa Motora) . CARDIOVASCULAR. 1-A- CARDIOTÓNICOS. com estes fármacos não devem ser estimulados a comer alimentos ricos em com arritmias requerem atenção especial no uso de diuréticos e cardiotônicos. C01A-Cardiotónicos . algunos de estos fármacos no está demostrado que tengan ninguna relación con el .. G04AB Fármacos usados en la disfunción erectil.

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Procedimiento de pulverizacion-solidificacion que usa un extrusor para preparar composiciones en multipartfculas de farmacos cristalinos Solidification-pulverization process using an extruder to prepare compositions in crystalline drugs multipartfculas.

Las multipartfculas son formas farmaceuticas muy conocidas que comprenden una multiplicidad de partfculas cuya totalidad representa la dosis terapeuticamente util deseada de un farmaco. The multipartfculas are well known dosage forms that comprise a cardiotlnicos of particles whose totality represents the desired therapeutically useful dose of a drug. Cuando se toman por via oral, las multipartfculas se dispersan por lo general libremente en el tracto gastrointestinal, maximizan la absorcion y minimizan los efectos secundarios.

When taken orally, the multipartfculas usually disperse caediotonicos in the gastrointestinal tract, maximize absorption, and minimize side effects. Una formulacion tfpica en multipartfculas consiste en un farmaco distribuido sustancialmente de afrmacos uniforme en un vehuculo.

A tfpica multipartfculas formulation consisting of a drug substantially uniformly distributed in vehuculo. Un procedimiento convencional para producir dichas multipartfculas es anadir el farmaco y el vehuculo a un deposito calentado para producir una mezcla fundida que se atomiza luego en gotitas y las gotitas se solidifican para formar las multipartfculas. A conventional process for producing such multipartfculas is adding the drug and vehuculo a tank heated to produce a molten mixture is then atomised into droplets and the droplets solidify to form the multipartfculas.

Sin embargo, los procedimientos de fabricacion de productos farmaceuticos comerciales requieren tfpicamente un tiempo medio de permanencia del farmaco en la mezcla fundida de varias horas o mas para la produccion economica de las multipartfculas. However, the manufacturing processes of commercial pharmaceutical products typically require an average residence time of the drug in the molten several hours or more for economic production of multipartfculas mixture.

Dichos tiempos medios de permanencia largos pueden conducir a una rapida degradacion del farmaco oa reacciones indeseables del farmaco con el vehuculo.

Such means long residence times may lead to rapid degradation of the drug or undesirable reactions of the drug with vehuculo.

EST3 – Methods and compositions for the delivery of a therapeutic agent – Google Patents

Debido a esto, los procedimientos farmaceuticos de fusion-solidificacion convencionales no se consideran utiles para preparar multipartfculas de farmacos termolabiles. Because of this, the pharmaceutical procedures conventional fusion-solidification are not considered useful for preparing multipartfculas of thermolabile drugs. Las cardiotonicps de EE. Cadriotonicos analgesico y el vehuculo se mezclan y se calientan despues a una temperatura suficientemente alta para extruir la mezcla en un cordon que tenga un diametro de 0,1 a 3 mm.

The analgesic and vehuculo are mixed and heated after a temperature high enough to extrude the mixture into a cord having a diameter of 0.

El cordon se enfna luego y se divide formando multipartfculas. The cord is then enfna and divides forming multipartfculas. No hay ninguna descripcion del uso de un atomizador para formar las multipartfculas a partir de material extruido, ni hay reconocimiento de una mejor estabilidad cardiotonkcos obtenida por el uso de un extrusor para formar la mezcla fundida.

No description of use of an atomizer to form multipartfculas from extruded material, nor is there recognition qrnmica better stability obtained by the use of an extruder to form the molten carddiotonicos. La patente de EE. El farmaco se deja fundir, dispersar o disolver en una masa fundida caliente de un vehuculo y se atomiza luego en una camara de aire en donde la temperatura es inferior al punto de fusion de los componentes, proporcionando con ello pelets solidificados esfericos.

The drug is allowed to melt, dispersed or dissolved in a hot melt of a vehuculo and then sprayed into a chamber where the air temperature is below the melting point of the components, thereby providing spherical pellets solidified. Se indica que el procedimiento es adecuado para sustancias termolabiles puesto que se utiliza la temperatura ambiente para secar los pelets.

It indicates that the procedure is suitable for thermolabile substances because the room temperature is used to dry the pellets.

Sin embargo, no hay descripcion del uso de un extrusor para producir una mezcla fundida que haya de ser atomizada, ni la necesidad de minimizar el tiempo medio de permanencia del farmaco en la mezcla fundida para mejorar su estabilidad qrnmica. However, no description of the use of an extruder to produce a molten mixture which is to be atomized, or the need to minimize the average residence time of the drug in the melt to improve its stability qrnmica mixture.

Los coloides se pueden preparar por un procedimiento de “cizallamiento subito” en el que la temperatura de un material de alimentacion se eleva hasta un punto en el que el vehuculo experimenta un flujo intrapartfculas. The cardiotonicis can be prepared by a process of “sudden shear” in csrdiotonicos the temperature of a feedstock is raised to a point where the vehuculo undergoes intrapartfculas flow.

El procedimiento de cizallamiento subito se dice que es un procedimiento de “flujo en fno” que no tiene largos tiempos de permanencia en el vehuculo y evita por tanto los problemas asociados con un historial de calor creado por los tiempos de permanencia largos. Subito shear procedure is said to be a process of “FNO flow” that has long residence times in the vehuculo and thus avoids the problems associated with a history of heat created by carduotonicos long residence times.

Una porcion del material pulverulento se funde en el esparcidor giratorio, recubriendo las partfculas no fundidas, que luego se descargan como partfculas mayores desde la periferia del esparcidor giratorio. A portion of the pulverulent material is melted in the rotary spreader, coating the unfused particles which then are discharged as larger particles from the periphery of the rotating spreader.

La solicitud de patente de EE. Tambien se reivindican una dosis unitaria de la misma, asf como el procedimiento para su preparacion y el uso de la formulacion y la dosificacion unitaria Also a unit dose thereof claimed, asf as the process for their preparation dardiotonicos the use of the formulation and unit dosage En una realizacion, la composicion farmaceutica solida incluye un vehnculo solido, incluyendo el vehnculo solido un sustrato y una capa de encapsulacion sobre el sustrato.

In one embodiment, the solid pharmaceutical composition includes a solid vehnculo, including solid vehnculo a substrate and an encapsulation layer on the substrate.

ES2611995T3 – Methods and compositions for the delivery of a therapeutic agent – Google Patents

La capa de encapsulacion puede incluir diferentes combinaciones de ingredientes activos, agente tensioactivo hidrofilo, tensioactivos lipofilos y trigliceridos y solubilizantes. The encapsulation layer may include different combinations of active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides and solubilizers.

En otra realizacion, la composicion farmaceutica solida incluye un vehnculo solido, estando formado el vehnculo solido de diferentes combinaciones de ingredientes activos, tensioactivos hidrofilos, tensioactivos lipofilos y trigliceridos y solubilizantes. In another embodiment, the solid pharmaceutical composition includes a solid vehnculo, the solid vehnculo different combinations of active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides and solubilizers being formed.

Las composiciones de dicha invencion se pueden utilizar para mejorar la administracion de ingredientes activos. The compositions of this invention can be used to improve the administration of active ingredients. A describes a pharmaceutical composition comprising a solid amorphous dispersion comprising a low solubility drug and enhancer concentration of polymer and a lipophilic microphase forming material.

Alternativamente, una dispersion solida amorfa que comprende un farmaco de baja solubilidad y un polfmero potenciador de la concentracion se administra conjuntamente con un material lipofilo formador de microfase para uso en un entorno in vivo. Alternatively, a solid amorphous dispersion comprising a low solubility drug and enhancer concentration of polymer is administered in conjunction with a lipophilic microphase-forming material for use in an in vivo environment.

El objetivo del estudio de Savolainen Marja et al. The aim of the study Marja Savolainen et al. Se uso enfriamiento con pulverizacion para formular el farmaco, los lfpidos polares y los polfmeros hidrofilos en multipartfculas en dispersion solida, que a continuacion se comprimieron.

Las multipartfculas se caracterizaron por espectroscopfas infrarroja con transformada de Fourier y Raman, difraccion de rayos X sobre polvo, microscopfa en platina caliente, microscopfa electronica de barrido y analisis de imagen.

The multipartfculas were characterized by infrared Fourier transform espectroscopfas and Raman, X-ray diffraction over powder, microscopfa hot stage, microscopfa electronic scanning and image analysis. La cristalinidad del felodipino habfa disminuido en todas las muestras, y la cantidad de felodipino cristalino variaba dependiendo de la composicion de la dispersion solida. Felodipine habfa crystallinity decreased in all samples, and the amount of crystalline felodipine varied depending on the composition of the solid dispersion.

Las partfculas eran esfericas variando el diametro medio de partfculas entre 20 y 35 pm.

The particles were spherical varying the average diameter of particles between 20 and 35 pm. La adicion de polfmero hidrofilo a la matriz amplio la distribucion del tamano de partfculas y aumento de la cantidad de aglomerados.

The addition of hydrophilic polymer to the matrix wide size distribution and particles increase the amount of agglomerates. La mayona de los patrones de disolucion prometedores se obtuvieron a partir de comprimidos que conteman gliceridos. The Mayona patterns promising solution were obtained from tablets conteman glycerides.

A describes a pharmaceutical composition comprising a solid amorphous dispersion of an inhibitor Protema transfer cholesteryl ester and an enhancer of polymer concentration.

A describes a process for preparing controlled release formulations of drugs for oral administration and solid dosage forms for controlled cardoitonicos of medicaments prepared therewith. Preferiblemente las formas farmaceuticas solidas de liberacion controlada de amoxicilina y acido clavulanico se preparan de acuerdo con el procedimiento de dicha invencion. Preferably the solid dosage forms controlled release amoxycillin and clavulanic acid prepared according to the procedure of this invention.

Tambien son metodos de dicha invencion el transporte de clavulanato y composiciones que contienen clavulanato. They are also methods of this invention the transport of clavulanate and compositions containing clavulanate. Por tanto, existe la necesidad en la tecnica de un procedimiento eficiente de fusion-solidificacion para formar multipartfculas que contengan farmacos termolabiles, en el que la degradacion del farmaco se mantenga en un nivel aceptablemente bajo.

Therefore, there is a need in the art for an efficient method of fusion-solidification to form multipartfculas containing thermolabile drugs, wherein drug degradation is maintained at an acceptably low level. Esta necesidad y otras que seran evidentes para un experto en la tecnica se cumplen por la presente invencion, que se resume y describe detalladamente a continuacion. This need and others that will be apparent to one skilled in the art are met by the present invention, which is summarized and described in detail below.

La invencion se refiere a un procedimiento para la farmaacos de multipartfculas qmmicamente estables que contienen farmacos como se define en la reivindicacion 1. The invention relates to a process for the formation of stable qmmicamente multipartfculas containing drugs as defined in claim 1.

Los inventores han descubierto que los inconvenientes de los procedimientos de fusion-solidificacion fsrmacos la tecnica anterior se pueden superar por el uso de un extrusor en combinacion con un atomizador, tal como un atomizador de disco giratorio.

The inventors have discovered that the drawbacks of the melting-solidification of the prior art can be overcome by the use of an extruder in combination with an atomizer such as a rotating disk atomizer. En este procedimiento, se forma una mezcla fundida, que comprende un farmaco termolabil y al menos un vehnculo usando un extrusor, tal como un extrusor de doble tornillo.

In this process, a molten mixture comprising a thermolabile drug and at least one vehnculo using an extruder such as a twin screw extruder is formed. La mezcla fundida se dirige a un atomizador para producir gotitas de la alimentacion fundida. The molten mixture is directed to an atomizer to produce droplets of the farmados feed. Las gotitas se solidifican para formar multipartfculas. Droplets solidify to form multipartfculas. En este procedimiento, el tiempo entre la formacion de la mezcla fundida y farmaco solidificacion de las multipartfculas es suficientemente corto, de manera que el farmaco en las multipartfculas tenga una mejora medible cqrdiotonicos la estabilidad qmmica, respecto a un control que consiste esencialmente en la misma composicion, preparada por esencialmente el mismo procedimiento pero en la que el farmaco tiene un tiempo medio de permanencia en la mezcla cadiotonicos de aproximadamente 60 minutos.

In this procedure, the time between the formation of the molten mixture and solidifying the multipartfculas is short enough so that the drug in multipartfculas have a measurable improvement qmmica stability relative to a control consisting essentially of the same composition prepared by essentially the same procedure but in which the drug has a mean residence time in the molten mixture about 60 minutes.

Las multipartfculas formadas por el procedimiento de la presente invencion pueden ser para liberacion inmediata, prolongada, retardada o controlada del afrmacos despues de la introduccion en un entorno de uso. The multipartfculas formed by the process of the present invention may be for immediate release, extended, delayed or controlled the drug after introduction into a use environment.

Como se usa en la presente memoria, un “entorno de uso” puede ser o bien el entorno in vivo del tracto gastrointestinal Gl de un animal tal como un mairnfero o un ser humano, o el entorno in vitro de una solucion de ensayo, tal como una solucion simulada de tampon de jugo gastrico o una solucion simulada de tampon intestinal.

As used herein, a “use environment” can be either the in vivo gastrointestinal tract Gl of an animal such environment as a mairnfero or a human, or the in vitro environment of a test solution as a simulated buffer solution gastric juice or simulated intestinal buffer solution. Illustrative solutions simulated gastric buffers include aqueous solutions comprising 0. Las directrices detalladas sobre la seleccion de las condiciones de procesamiento, los vehfculos y sus interrelaciones se exponen en la descripcion detallada de las realizaciones preferidas siguientes Farmacow on selection of processing conditions guidelines, vehfculos and their interrelationships are set forth in the detailed description of the preferred embodiments Las composiciones formadas por el procedimiento de la presente invencion comprenden una pluralidad de “multipartfculas” que contienen farmacos.

El termino “multipartfculas” pretende abarcar una forma farmaceutica que comprende una multiplicidad de partfculas cuya totalidad representa la dosis terapeuticamente util deseada del farmaco en cuestion. The compositions formed by the process of the present invention comprise a plurality of “multipartfculas” containing drugs. The term “multipartfculas” is intended to embrace farmwcos dosage form comprising a multiplicity of particles whose totality represents the desired therapeutically useful dose of the drug in question.

Las partfculas tienen generalmente un diametro medio de aproximadamente 10 a aproximadamente 3. The particles generally have an average diameter of about 10 to about pm, preferably 50 to p, and more preferably to pm.

Las multipartfculas son formas farmaceuticas ventajosas debido a que se pueden utilizar en formas farmaceuticas ajustables de acuerdo con el peso de un animal individual que necesite tratamiento, simplemente ajustando la masa de las partfculas en la forma farmaceutica para adaptarse al peso del animal.

The dosage forms are advantageous multipartfculas because adjustable may be used in dosage forms according to the weight of an individual animal in need of treatment by simply adjusting the mass of particles in the dosage form to suit the weight of the animal.

DIN 1055-1 PDF

DIN () Action On Structures – Part 1: Densities And Weights Of Building Materials, Structural Elements And Stored Materials This standard is. Berlin: Beuth DIN Design loads for buildings – Part I: Store materials, building materials and structural members. dead load and angle of friction. German design standards DIN and DIN Corresponding to the new generation of German standards DIN c) several parts: DIN 10, Fig .

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LIBRO PEDRO URDEMALES PDF

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