Los factores de la coagulación de la vía extrínseca se activan al producirse el La coagulación también puede activarse por la vía intrínseca al entrar en. El factor Xa desempeña un papel central en la cascada de coagulación debido a que ocupa un punto en el que convergen la vía intrínseca y la extrínseca. trabajo de cecilia lópez sampellegrini grado: enfermería. primer curso. asignatura: bioquímica, nutrición dietética. profesora: eva maría giner las enzimas su.

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Screening for anticoagulant substances in some marine macroalgae. A simple method of studying the generation of thrombin in recalcificated plasma.

The extracts of Anadyomene stellata Wulfen C. A total of five species were active in standard clotting test, three of Chlorophyta, one from Phaeophyta and one from Rhodophyta. The mixture was homogenized in a Waring blender, centrifuged at x g for 15 minutes and supernatant filtered through 0. Human plasma was obtained by venous puncture with a disposable syringe, blood was combined with 3.

It has been done research in anticoagulant activity of polysaccharides and glycosaminoglycans of diverse sources such as: Propiedades anticoagulantes de extractos de algas marinas mexicanas: Structure and anticoagulant activity of a fucosylated chondroitin sulfate from echinoderm.

Inhibition of Factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting both thrombin formation and development of thrombi.

Translation of “formación de trombina” in English

Materials and methods The samples for this study were manually collected from the seven localities described above, from the Gulf of Mexico and Mexican Caribbean sea during May to October figure 1were classified by genus and transported frozen to the laboratory using solid CO 2. Forty nine seaweed species collected off shore of several localities of Gulf of Mexico and Mexican Caribbean sea were screened in order to detect anticoagulant activity caascada both intrinsic and extrinsic pathways of clot formation.


Chemical structure of antithrombin-active Rhamnan sulfate from Monostroma nitidum.

Current views on blood coagulation and haemostatic mechanism. It is known that species of Chlorophyta synthesized polydisperse heteropolysaccarides casdada low sulfate content, glucoronoxilorhamans, glucoronoxilorhamagalactans and xyloarabinogalactans, some of them with a potent anticoagulant activity Uehara et al.

Factor VIII

Our results showed four species with similar activity susceptible of further research for isolation and characterizations of active substances. Journal of Applied Phycology These variation has been suggested as been influenced by geographical factors such as climate and locality and has been probed with primary metabolites as lectins by Ingram and Fabregas et al.

In the central and inrtinseca zones there are patches of sea-grass Halodule wrightiithe western part with algae. Bioscience Biotechnology and Biochemistry Similar results of slightly anticoagulant potency were observed but in thrombin time test for C. Journal of Phycology Standardized plasma coagulation tests thrombin and prothrombin time were used.

Epiphytes were removed carefully from the algae under the microscope to avoid contamination. Anticoagulant activity, marine algae, Gulf of Mexico, heparin. The extracts could act preventing the conversion of prothrombin coagulacino thrombin, also they could act stopping the transformation of fibrinogen to convert it to fibrin o even in the polymerization of this last molecule.


Agardh Rhodophyta retarded the coagulation process of human plasma in both anticoagulant tests for less than two minutes period and more than cascasa minute. This last molecule is a sulfated glicosaminoglycan used in oral therapy for anticoagulant disorders. The sites of collection of Veracruz state were: Thrombosis is a health problem that affects many people in the world. We can suggest these four species as a sources of new anticoagulant substances.

CASCADA DE COAGULACION by mitzy sabrina rodriguez anaya on Prezi

On the quantitative estimation of prothrombin. Results Results for algal extracts in both anticoagulant tests are in table 1.

The reason for using a general extraction method of molecules extracts from algae in saline or PB as Deacon-Smith and Rogers and Deacon-Smith et al. Occurrence of heparin in the invertebrate Styela plicata Tunicata extginseca restricted to cell layers facing the outside environment.

Further data on the structure of brown seaweed fucans: Anticoagulant activity in extracts of British marine algae. These examples may contain rude words based on your search. Revista de la Sociedad Mexicana de Historia Natural Other seven species presented a slightly anticoagulant activity.