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Benzoyl peroxide (BPO) has been well established as a common medication for acne vulgaris in many countries (e.g. in Europe and the USA). Jual BPO Jual Benzoil perokside. Jual Benzoil Peroksida Jual Caffeine Anhydrous Jual Ceramide Jual Cajuput Oil Jual Centella Asiatica Jual Cetyl Alcohol. Benzoyl peroxide (BPO) is an organic compound in the peroxide family. It consists of two benzoyl groups bridged by a peroxide link. It is one of the most.

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Benzoyl peroxide BPO has been well established as a common medication for acne vulgaris in benoil countries e. In Japan, the use of BPO for acne treatment was approved inand the results of clinical trials in Japanese patients have recently been reported.

This review compares clinical study results between Japanese and Western patients. Two reports of Japanese studies were also selected by using the same criteria. Efficacy was assessed by comparing the mean difference between the BPO and the vehicle groups for reduction rate in the number of lesions from baseline, benzlil there were no differences between Japanese and Western patients. Benoil assessment also showed that the incidence of adverse events was higher in Japanese patients than in Western patients, but the characteristics of the adverse events were not different.

Therefore, we conclude that there are no significant differences in the efficacy and safety of BPO between these patient populations.

Acne vulgaris is a chronic inflammatory disease that often affects the hair follicle sebaceous glands on the face, chest and back. The pathogenesis of acne vulgaris is a complex process involving abnormal lipid metabolism, dyskeratosis and bacterial growth. In the meantime, in Japan, BPO was approved in for the treatment of acne vulgaris and has been on the market sinceand therefore clinical data of Japanese patients has only recently become available.

Reports hit by the search were further screened on the basis of their titles and abstracts.

These two Japanese studies were independent venzoil separate clinical studies and the results were generated from different subject groups. Clinical studies outside Japan were performed in North America and Europe, which means as a result that this review compared Japanese studies in Japanese patients with Western studies in Western patients mainly Caucasians.

In the following comparison, references were limited to studies with gel formulations of BPO as the Japanese studies used. For comparison of efficacy, references that reported the mean reduction rate in number of lesions from baseline were selected, and four studies in Western patients and two studies in Japanese patients were used for the comparison.

To investigate the safety profile, we focused on the reports that included incidences of adverse events AEand eight studies in Western patients and two studies in Japanese patients were selected. The mean or median percentage reduction of each study is summarized by lesion type Fig. The BPO concentration of the study drugs ranged 2. It has been reported that there is no difference in the efficacy of BPO preoksida the range of a concentration of 2. Percentage reduction and mean difference in percentage reduction of inflammatory lesion IL counts from baseline between the benzoyl peroxide BPO and the vehicle groups.

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Percentage reduction and mean difference in percentage reduction of total lesion TL counts from baseline between the benzoyl peroxide BPO and the vehicle groups.

Jual Benzoil Peroksida

We consider that there is no significant difference in percentage reduction in inflammatory lesion count between the Western and the Japanese studies for both of the BPO and the vehicle groups. In addition, the mean differences in percentage reduction in inflammatory lesion count in the Japanese studies were within the range observed in the Western studies.

Therefore, we conclude that the efficacy profiles of BPO for the inflammatory lesions are similar between the Western and the Japanese studies. We consider that there is no significant difference in percentage reduction in total lesion count between the Western and the Japanese studies for both the BPO and vehicle groups.

However, the mean differences in percentage reduction in total lesion count in the Japanese studies were not within the range observed in the Western studies.

This was because only two studies in the Western studies calculated the mean percentage reduction in total lesion count. In both Western and Japanese studies, perosida following safety characteristics were commonly reported: Therefore, we conclude that there are no qualitative differences in the safety profile of BPO between the Western and Japanese patient populations.

It has been reported that the skin barrier structure of Asians, including Japanese, is weaker than that of Caucasians, 14 which may be a reason for the higher incidence of AE in Japanese studies.

Benzoyl Peroxide Topical

Another possible factor for a higher incidence of AE in Japanese studies was the use of moisturizers. The two Western studies required the concomitant treatment with a moisturizer for subjects who were assessed to have dry skin by the investigator. Acne vulgaris frequently relapses when treatment is discontinued after symptoms have improved; thus, remission has to be maintained, even after inflammation has resolved.

On the basis of these results, we concluded that no new safety concerns due to prolonged treatment would arise after the early treatment phase. The main mechanism of action of BPO is believed to be oxidative activity at the application site, for which little ethnic difference is expected. In this article, we compared the results of clinical studies performed in Japan with those performed in the USA and Europe.

However, the comparison was based on historical data, and we should account for its limitations. Baseline severity of acne symptoms of participants, variability in the evaluation when counting lesions and recognition of AE may be different between studies and therefore affect the evaluation of safety and efficacy.

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Furthermore, this study included a change for the worse in local skin tolerability score as an AE, and this could also increase the incidence rate of AE in that study. Regarding the efficacy, the results of the Japanese studies are within the range of fluctuations of the studies performed in the USA and Europe, suggesting that there are no differences between these patient populations.

Although the safety assessment of the Japanese studies suggested that AE at the application site occurred more often in Japanese patients than Western patients, most of the AE were mild.

Except for the difference in the frequency of AE, there were no differences in their respective safety profiles.

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This review was sponsored by Maruho Co. Ltd at the time of the perokssida. Editorial assistance in the preparation bennzoil this manuscript was provided by WysiWyg Co. National Center for Biotechnology InformationU. The Journal of Dermatology. Published online Aug 9. Ltd, Kyoto, Japan, 3 Present address: Author information Article notes Copyright and License information Disclaimer.

Received Nov 16; Accepted Jun Abstract Benzoyl peroxide BPO has been well established as a common medication for acne vulgaris in many countries e.

Introduction Acne vulgaris is a chronic inflammatory disease that often affects the hair follicle sebaceous glands on the face, chest and back. Table 1 Selected references. Open in a separate window.

Table 2 Incidences of adverse events. Limitations In this article, we compared the results of clinical studies performed in Japan with those performed in the USA and Europe. Conflict of Interest This review was sponsored by Maruho Co. Acknowledgment Editorial assistance in the preparation of this manuscript was provided by WysiWyg Co. Jpn J Dermatol ; J Dermatol ; J Am Acad Dermatol ; Role of lipids in augmenting the antibacterial activity of benzoyl peroxide against Propionibacterium acnes.

Antimicrob Agents Chemother ; Skin Pharmacol Physiol ; Evaluating clinical trial design: Arch Dermatol Res ; Int J Dermatol ; Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin.

Dermatol Sci ; Br J Dermatol ; Safety and efficacy of clindamycin phosphate 1.

Benzoyl peroxide – DrugBank

J Drugs Dermatol ; An aqueous gel fixed combination of clindamycin phosphate 1. Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin peroksdia benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris.

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